Opportunity Information: Apply for W81XWH 19 NFRP NIA

The DoD Neurofibromatosis Research Program (NFRP) New Investigator Award is a U.S. Department of Defense funding opportunity designed to help build and expand the neurofibromatosis (NF) research workforce. Its central goal is to support promising early-stage independent investigators who are developing their own research programs, as well as to encourage established scientists from other disciplines to pivot into NF research. A key feature of this mechanism is that applicants do not need prior experience working specifically in NF to be eligible, which makes it a practical entry point for researchers bringing new tools, perspectives, or technologies to the field. At the same time, if a Principal Investigator has limited NF background, the program strongly encourages including a collaborator who already has NF expertise, helping ensure the project is grounded in the realities and current knowledge of the disease area.

From a scientific scope perspective, the award is broadly open to projects across essentially any stage or phase of research, as long as the work is not a clinical trial. That means applicants can propose basic, translational, preclinical, or other non-trial research activities relevant to NF, but they must stay clear of clinical trial execution. Another important requirement is that applications must be supported by preliminary and/or published data that connects directly to NF and to the proposed study. In practice, this signals that the program is looking for ideas that are already feasible and evidence-informed, even if the investigator is new to NF, rather than purely speculative concepts without a foundation.

Administratively, this opportunity was issued by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It was posted under Funding Opportunity Number W81XWH 19 NFRP NIA and falls under the Science and Technology and other Research and Development activity category (CFDA 12.420). The opportunity category is discretionary, and awards may be made as either grants or cooperative agreements, depending on the structure and level of agency involvement anticipated. Eligibility is listed as unrestricted, meaning it is open to a wide range of applicant organization types, subject to any additional clarifications provided in the full announcement.

In terms of timing and scale, the opportunity was created on March 11, 2019, with an original closing date of June 6, 2019. The notice anticipated making about three awards. The listed award ceiling is shown as 0, which typically indicates that the maximum funding level was not specified in that particular summary field and would need to be confirmed in the full funding announcement or associated program guidance. Overall, the award is positioned as a career-building mechanism aimed at bringing capable investigators into NF research or helping them deepen and sustain an emerging NF-focused research trajectory, with an emphasis on credible, data-supported non-clinical-trial projects.

  • The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis, New Investigator Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on Mar 11, 2019.
  • Applicants must submit their applications by Jun 06, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs): DoD Neurofibromatosis Research Program (NFRP) New Investigator Award

What is the DoD NFRP New Investigator Award?

The DoD Neurofibromatosis Research Program (NFRP) New Investigator Award is a U.S. Department of Defense funding opportunity intended to build and expand the neurofibromatosis (NF) research workforce. It supports early-stage independent investigators establishing their own research programs and also encourages established scientists from other disciplines to transition into NF research.

What is the main purpose of this award?

The central goal is workforce development in NF research. The mechanism is designed to help promising investigators begin or strengthen an NF-focused research trajectory by funding credible, evidence-informed projects that are relevant to neurofibromatosis.

Who is this award intended for?

This opportunity is aimed at (1) early-stage independent investigators developing their own research programs and (2) established investigators in other scientific disciplines who want to pivot into NF research.

Do applicants need prior neurofibromatosis (NF) research experience to be eligible?

No. A key feature of this mechanism is that prior NF-specific experience is not required for eligibility. This is explicitly positioned as an entry point for researchers who can bring new tools, perspectives, or technologies into the NF field.

If a Principal Investigator has limited NF experience, is collaboration recommended?

Yes. If the Principal Investigator has limited NF background, the program strongly encourages including a collaborator who already has NF expertise. This is intended to help ensure the work is well-grounded in current knowledge and practical realities of the NF disease area.

What types of research are allowed under this award?

The scientific scope is broadly open across essentially any stage or phase of research, as long as the work is not a clinical trial. This includes basic, translational, preclinical, or other non-trial research activities relevant to neurofibromatosis.

Are clinical trials allowed?

No. Projects must stay clear of clinical trial execution. The opportunity supports non-clinical-trial research only.

Is preliminary or published data required?

Yes. Applications must be supported by preliminary and/or published data that connects directly to NF and to the proposed study. The program is looking for feasible, evidence-informed concepts rather than purely speculative ideas without a foundation.

Does the required data need to relate to both NF and the specific proposed work?

Yes. The information provided indicates the preliminary and/or published data must connect directly to neurofibromatosis and to the proposed study, signaling a clear linkage between evidence, NF relevance, and the planned research activities.

Which agency issued this funding opportunity?

This opportunity was issued by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA).

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number provided is W81XWH 19 NFRP NIA.

What activity category is associated with this opportunity?

The opportunity falls under the Science and Technology and other Research and Development activity category and is associated with CFDA 12.420.

What is the opportunity category?

The opportunity category is discretionary.

What types of awards may be made under this opportunity?

Awards may be made as either grants or cooperative agreements, depending on the structure of the project and the level of agency involvement anticipated.

What does it mean that awards may be grants or cooperative agreements?

Based on the provided information, the mechanism can be structured either as a grant or a cooperative agreement, with the deciding factor being the expected level of involvement by the agency. The specific structure would be determined as part of the award process.

Who is eligible to apply?

Eligibility is listed as unrestricted, meaning it is open to a wide range of applicant organization types, subject to any additional clarifications that may exist in the full announcement.

How many awards were anticipated?

The notice anticipated making about three awards.

When was this opportunity created and when did it close?

The opportunity was created on March 11, 2019, and the original closing date was June 6, 2019.

What is the maximum funding amount (award ceiling)?

The listed award ceiling is shown as 0 in the summary. This typically indicates the maximum funding level was not specified in that summary field and would need to be confirmed in the full funding announcement or associated program guidance.

Is this award primarily a career-building mechanism?

Yes. The opportunity is positioned as a career-building mechanism intended to bring capable investigators into NF research or help them deepen and sustain an emerging NF-focused research path, with emphasis on credible, data-supported non-clinical-trial projects.

Can researchers from outside the NF field apply with a new NF-focused idea?

Yes. The program is designed to encourage established scientists from other disciplines to pivot into NF research. Prior NF-specific experience is not required, though including NF expertise via collaboration is strongly encouraged when the PI has limited NF background.

Does the award support projects at different stages of research development?

Yes. The scope is broadly open across essentially any stage or phase of research, including basic, translational, and preclinical work, as long as the project is not a clinical trial and is supported by preliminary and/or published NF-relevant data tied to the proposed study.

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Funding Number: 19 569
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Funding Number: W81XWH 19 PRCRP IPA
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Funding Number: PD 19 7680
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Funding Number: W81XWH 19 LCRP TRPA
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