Opportunity Information: Apply for RFA DA 25 077
The HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional) funding opportunity (RFA-DA-25-077) is a National Institutes of Health (NIH) discretionary grant designed to move evidence-based strategies into real-world use to help reduce overdose deaths. It sits under the HEAL (Helping to End Addiction Long-term) Initiative and is positioned as a "parent" RFA for the HEAL Translation to Practice Team, meaning it provides a broad umbrella for projects that translate, disseminate, and implement research findings in community, health care, and other applied settings. The central emphasis is on practical, translational dissemination and implementation (D and I) research that can make measurable progress against the overdose crisis, including work that addresses the intersection between pain and opioid use disorder (OUD). Clinical trials are optional under this R33 mechanism, so applicants may propose trial or non-trial implementation research depending on what best fits their aims.
A key feature of this opportunity is that it is meant to operate alongside targeted NIH Notices of Special Interest (NOSIs) that define more specific priority areas. For fiscal year 2025, the currently named NOSIs include a Workforce NOSI (supporting implementation approaches that strengthen and expand the workforce needed to deliver effective pain and OUD-related care), an Exposure to Violence NOSI (recognizing the strong links between violence exposure, trauma, substance use, and overdose risk), and a Leveraging Inpatient Hospitalizations NOSI (focusing on how hospital-based touchpoints and transitions of care can be used to identify risk and connect people to effective services). In practice, this means applicants can align their proposals with the broader parent RFA goals while also tailoring their projects to one of these highlighted lanes when appropriate. The RFA also notes that there is a companion R61/R33 opportunity, signaling that NIH is supporting both staged early-development-to-expansion pathways (R61/R33) and more directly implementation-focused R33 projects under the Translation to Practice portfolio.
The expected scope is reflected in the award parameters. The listed award ceiling is $750,000, and NIH anticipates making around 12 awards. The opportunity is categorized under "Education, Health, Income Security and Social Services" and is associated with multiple CFDA numbers (93.213, 93.242, 93.273, 93.279, 93.865, 93.866), which indicates the funding aligns with several NIH program authorities relevant to substance use, mental health, health services, and related translational work. The posting was created on 2024-12-17, and the original closing date is 2025-03-20, which effectively sets the timeline for applicants to prepare implementation-oriented proposals that are ready to operate in real settings and generate actionable results.
Eligibility is broad and intentionally inclusive of the kinds of partners needed to implement overdose and OUD-related solutions at scale. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with and without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; and other entities. The RFA further highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, there are clear restrictions: non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible.
Overall, the opportunity is aimed at bridging the gap between what research has shown to work and what is actually delivered in clinics, hospitals, community programs, and other frontline systems that touch people at risk of overdose or living with OUD and pain. Competitive projects under this RFA would be expected to focus on real-world adoption, integration, and sustainability of evidence-based practices; measure implementation outcomes and, where relevant, health outcomes; and address barriers that prevent effective interventions from reaching the people and settings where they are most needed.Apply for RFA DA 25 077
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.242, 93.273, 93.279, 93.865, 93.866.
- This funding opportunity was created on 2024-12-17.
- Applicants must submit their applications by 2025-03-20. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: HEAL Initiative - Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional) (RFA-DA-25-077)
What is this funding opportunity?
This is a National Institutes of Health (NIH) discretionary grant funding opportunity titled "The HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional)" under announcement number RFA-DA-25-077. It supports projects that move evidence-based strategies into real-world use to help reduce overdose deaths.
What is the main goal of the RFA?
The central goal is to bridge the gap between research findings and what is actually delivered in real settings (clinics, hospitals, community programs, and other applied systems). The emphasis is on practical dissemination and implementation (D and I) research that can produce measurable progress against the overdose crisis.
How does this fit within the HEAL Initiative?
This opportunity sits under the HEAL (Helping to End Addiction Long-term) Initiative and supports translation-to-practice work intended to help end the overdose crisis by accelerating real-world adoption of evidence-based approaches.
What does it mean that this is a "parent" RFA?
It means the RFA serves as a broad umbrella for a range of projects within the HEAL Translation to Practice portfolio. It is designed to work alongside targeted Notices of Special Interest (NOSIs) that define more specific priority areas.
Are clinical trials required?
No. Under this R33 mechanism, clinical trials are optional. Applicants may propose trial or non-trial implementation research, depending on what best fits their aims.
What types of research are encouraged?
The opportunity prioritizes dissemination and implementation (D and I) research focused on practical, translational work in real-world settings. Competitive projects would be expected to focus on adoption, integration, and sustainability of evidence-based practices; measurement of implementation outcomes and, where relevant, health outcomes; and addressing barriers that prevent effective interventions from reaching the settings and people who need them.
Does the RFA include work related to pain and opioid use disorder (OUD)?
Yes. The RFA explicitly notes interest in work that addresses the intersection between pain and opioid use disorder (OUD), within the broader context of reducing overdose deaths.
How do the Notices of Special Interest (NOSIs) relate to this RFA?
The RFA is meant to operate alongside targeted NIH NOSIs that highlight more specific priority lanes. Applicants can align with the broader parent RFA goals while also tailoring a project to one of the named NOSI areas when appropriate.
What NOSI priority areas are named for fiscal year 2025?
The information provided names three FY2025 NOSIs: (1) a Workforce NOSI, (2) an Exposure to Violence NOSI, and (3) a Leveraging Inpatient Hospitalizations NOSI.
What is the focus of the Workforce NOSI?
The Workforce NOSI supports implementation approaches that strengthen and expand the workforce needed to deliver effective pain-related and OUD-related care.
What is the focus of the Exposure to Violence NOSI?
The Exposure to Violence NOSI recognizes links between violence exposure, trauma, substance use, and overdose risk, and supports implementation-oriented work responsive to those connections.
What is the focus of the Leveraging Inpatient Hospitalizations NOSI?
This NOSI focuses on how hospital-based touchpoints and transitions of care can be used to identify risk and connect people to effective services, leveraging inpatient settings as intervention and linkage opportunities.
Is there a related or companion funding opportunity?
Yes. The RFA notes a companion R61/R33 opportunity, indicating NIH support for both staged early-development-to-expansion pathways (R61/R33) and more directly implementation-focused R33 projects within the Translation to Practice portfolio.
What is the award ceiling?
The listed award ceiling is $750,000.
How many awards does NIH expect to make?
NIH anticipates making around 12 awards.
What general topic area is this opportunity categorized under?
The opportunity is categorized under "Education, Health, Income Security and Social Services."
What CFDA numbers are associated with this opportunity?
The opportunity is associated with multiple CFDA numbers: 93.213, 93.242, 93.273, 93.279, 93.865, and 93.866.
When was this opportunity posted?
The posting was created on 2024-12-17.
What is the closing date?
The original closing date is 2025-03-20.
Who is eligible to apply?
Eligibility is broad and includes: state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with and without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; and other entities.
Are U.S. territories eligible?
Yes. U.S. territories or possessions are listed among eligible applicant types.
Are faith-based and community-based organizations eligible?
Yes. The RFA highlights faith-based or community-based organizations as eligible applicant types.
Are minority-serving institutions specifically included?
Yes. The RFA highlights additional eligible applicant types that include Alaska Native and Native Hawaiian Serving Institutions, AANAPISISs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are listed among the additional eligible applicant types.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply.
Can a U.S. organization include a non-U.S. (foreign) component in its application?
No. Non-domestic components of U.S. organizations are also not eligible.
What kinds of settings are projects expected to operate in?
Projects are intended to operate in real-world, applied settings such as community programs, health care systems, clinics, hospitals, and other frontline systems that touch people at risk of overdose or living with OUD and pain.
What outcomes are projects expected to measure?
Projects would be expected to measure implementation outcomes and, where relevant, health outcomes, while demonstrating progress on real-world adoption, integration, and sustainability of evidence-based practices.
What is the overarching problem this opportunity is trying to address?
The overarching focus is reducing overdose deaths by translating evidence-based research into practice and addressing barriers that keep effective interventions from being delivered at scale in the places they are needed most.
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| Funding Opportunity |
|---|
| HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional) Apply for RFA DA 25 078 Funding Number: RFA DA 25 078 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Project Grant (Parent R21 Basic Experimental Studies with Humans Required) Apply for PA 25 307 Funding Number: PA 25 307 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Data Analysis and Sharing Center (DASC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed) Apply for RFA HL 26 010 Funding Number: RFA HL 26 010 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,000,000 |
| Limited Competition: Clinical Research Sites (CRS) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trial Not Allowed) Apply for RFA HL 26 009 Funding Number: RFA HL 26 009 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,400,000 |
| Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed) Apply for RFA HL 26 011 Funding Number: RFA HL 26 011 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,000 |
| Single Source: National Longitudinal Study of Adolescent to Adult (Add) Health Wave VII (U01 Clinical Trial Not Allowed) Apply for RFA AG 26 001 Funding Number: RFA AG 26 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional) Apply for PAR 25 383 Funding Number: PAR 25 383 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed) Apply for RFA DA 27 004 Funding Number: RFA DA 27 004 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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