Opportunity Information: Apply for PAR 19 337
This funding opportunity, titled "Limited Competition: Competitive Revision Awards for the Clinical and Translational Science Award (CTSA) Program (U54 Clinical Trial Optional)" (PAR-19-337), is a National Institutes of Health (NIH) cooperative agreement designed specifically for institutions that already hold an active CTSA Program hub award (the UL1 award mechanism). The central intent is to provide additional, competitively awarded funding through a competitive revision application, which is the NIH term for what used to be called a competitive supplement. In practical terms, the NIH is not looking to fund routine extensions of ongoing CTSA activities. Instead, it is seeking proposals that add new, substantial work that goes beyond what was originally approved and funded under the parent UL1 award, while still advancing the overall goals and mission of the CTSA Program.
The program focus is on translational science projects that are described as highly innovative and highly impactful, with an emphasis on three broad types of activity: demonstration, dissemination, and implementation. That means the revision funding is meant to help CTSA hubs show that a promising translational approach works in a real-world or hub-relevant setting (demonstration), spread effective translational methods, tools, or practices to broader audiences or partner sites (dissemination), and embed evidence-based translational practices into routine operations or systems in a way that can be sustained and scaled (implementation). The common thread across these categories is that the work should be meaningful for translational science itself and aligned with CTSA priorities, rather than being a minor add-on to an existing project. The FOA also notes that clinical trials are optional, signaling that projects may include a clinical trial component if appropriate, but a trial is not required to be responsive.
Eligibility is limited by design. The competition is restricted to current CTSA hub awardees with active UL1 awards, reflecting the "limited competition" structure and the intent to build directly on established CTSA infrastructure. The eligible applicant type listed includes public and state-controlled institutions of higher education, which aligns with the typical institutional homes of CTSA hubs. At the same time, the FOA makes clear restrictions around foreign participation: non-U.S. (non-domestic) entities and non-U.S. components of U.S. organizations are not eligible to apply as applicants. However, foreign components are allowed as NIH defines them in its Grants Policy Statement, which generally means a U.S. applicant institution may include certain scientifically justified foreign elements or collaborations under NIH rules, even though the applicant organization itself must be domestic and meet the FOA's eligibility constraints.
Administratively, this opportunity falls under the health category and is associated with CFDA number 93.350. It uses the cooperative agreement funding instrument, which typically implies substantial NIH programmatic involvement compared to a standard grant. While the summary data provided does not list an expected number of awards, it does specify an award ceiling of $750,000, indicating the maximum amount that can be requested or awarded under this revision mechanism. The FOA was created on 2019-08-07, and the original closing date provided is 2021-02-16, which is the date by which applications for that cycle were due.
Overall, the opportunity is best understood as a targeted infusion of competitively awarded funds intended to help existing CTSA hubs tackle new, ambitious translational science efforts that they could not have proposed under the original UL1 scope. The expectation is that funded projects will not only be innovative locally, but also generate lessons, approaches, or models that can be demonstrated and then broadly disseminated or implemented to strengthen translational science capacity and impact across the CTSA consortium.Apply for PAR 19 337
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Competitive Revision Awards for the Clinical and Translational Science Award (CTSA) Program (U54 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.350.
- This funding opportunity was created on 2019-08-07.
- Applicants must submit their applications by 2021-02-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education.
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| Explainable Artificial Intelligence for Decoding and Modulating Neural Circuit Activity Linked to Behavior (R01 Clinical Trial Optional) Apply for PAR 19 344 Funding Number: PAR 19 344 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Institutionally-Focused Research Education Award to Promote Diversity (UE5 - Clinical Trial Not Allowed) Apply for PAR 19 342 Funding Number: PAR 19 342 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 - Independent Clinical Trial Not Allowed) Apply for PAR 19 343 Funding Number: PAR 19 343 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Investigations on Primary Immunodeficiency Diseases/Inborn Errors of Immunity (R21 Clinical Trial Not Allowed) Apply for PAR 19 346 Funding Number: PAR 19 346 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Investigations on Primary Immunodeficiency Diseases/Inborn Errors of Immunity (R03 Clinical Trial Not Allowed) Apply for PAR 19 347 Funding Number: PAR 19 347 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| Limited Competition: Exploratory and Developmental Research Grant Program for NIAID K01/K08/K23 Recipients (R21 Clinical Trial Not Allowed) Apply for PAR 19 351 Funding Number: PAR 19 351 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Expanding Malawi HIV/AIDS Prevention with Local Organizations Working for an Effective Epidemic Response (EMPOWER) Apply for 72061219RFA00005 Funding Number: 72061219RFA00005 Agency: Malawi USAID-Lilongwe Category: Health Funding Amount: $33,000,000 |
| Health Workforce Improvement Program (HWIP) Apply for 72066319RFA00005 Funding Number: 72066319RFA00005 Agency: Ethiopia USAID-Addis Ababa Category: Health Funding Amount: $39,500,000 |
| Multisite Clinical Center Common Fund Acute to Chronic Pain Signatures Program: Acute Peri-operative Pain or Musculoskeletal Trauma (UM1 Clinical Trial Optional) Apply for RFA RM 19 013 Funding Number: RFA RM 19 013 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Myeloid-Derived Suppressor Cells (MDSCs) as Potential Therapeutic Targets in TB/HIV (R21 Clinical Trial Not Allowed) Apply for PAR 19 364 Funding Number: PAR 19 364 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
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| Trans-Agency Blood-Brain Interface Program (R61/R33 - Clinical Trials Not Allowed) Apply for RFA HL 20 021 Funding Number: RFA HL 20 021 Agency: National Institutes of Health Category: Health Funding Amount: $425,000 |
| Mechanistic Basis of TDP-43-dependent Pathobiology in Common Dementias (R01 Clinical Trial not Allowed) Apply for RFA NS 20 005 Funding Number: RFA NS 20 005 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Peripheral Pathology in the Lewy Body Dementias (R01 Clinical Trial Not Allowed) Apply for RFA NS 20 014 Funding Number: RFA NS 20 014 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed) Apply for PAR 19 370 Funding Number: PAR 19 370 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
| Institutional Research and Academic Career Development Awards (IRACDA) (K12 - Independent Clinical Trial Not Allowed) Apply for PAR 19 366 Funding Number: PAR 19 366 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Maximizing Investigators' Research Award (R35 - Clinical Trial Optional) Apply for PAR 19 367 Funding Number: PAR 19 367 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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