Opportunity Information: Apply for PA 20 204

The Mentored Patient-Oriented Research Career Development Award (K23) is an NIH career development grant designed to help early-career clinician-researchers build the skills, experience, and publication track record needed to become independent investigators in patient-oriented research. It is specifically aimed at individuals who already hold a clinical doctoral degree and have made a clear commitment to conducting research that directly involves human participants. In this particular parent announcement, the focus includes independent basic experimental studies with humans, meaning the proposed work should involve prospective or direct interaction with people (or their identifiable data or specimens in ways that meet NIH definitions of human subjects research) and should be structured as a mentored career development experience rather than a standalone research project. The core idea is that NIH funds protected time, structured training, and supervised research so the candidate can transition from mentored work into an independent research career.

This opportunity is issued by the National Institutes of Health as a discretionary grant under Funding Opportunity Number PA-20-204. The funding activity category is listed broadly across areas such as education, environment, health, and social services, reflecting NIH's wide mission and the fact that multiple NIH Institutes and Centers may participate depending on the scientific topic. The opportunity is associated with multiple CFDA numbers (including 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.361, 93.853, 93.865, 93.866, and 93.867), which typically correspond to different NIH Institutes and Centers that may support K23 applications aligned with their program priorities.

Eligibility is broad at the organizational level, covering many types of U.S.-based applicants that can administer NIH grants. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; and Native American tribal organizations other than federally recognized tribal governments. The announcement also allows nonprofit organizations, whether they have 501(c)(3) status or not (as long as they are not institutions of higher education for those categories), and it permits for-profit organizations (other than small businesses) as well as small businesses. In addition, NIH explicitly highlights a range of institution types and community-centered organizations as "other eligible applicants," including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible agencies of the federal government, and U.S. territories or possessions.

At the same time, the announcement draws clear boundaries around foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations) and non-domestic (non-U.S.) foreign institutions are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" are allowed when they meet NIH's definition in the NIH Grants Policy Statement, which typically means that part of the project may involve a significant element being conducted outside the U.S. under the U.S. applicant's award, subject to NIH review and approval. Practically, this setup is meant to keep the award anchored at an eligible U.S. organization while still permitting specific international elements when scientifically justified.

The original closing date listed for this opportunity is May 7, 2024, and the opportunity was created on May 11, 2020. The source information provided does not list an award ceiling or an expected number of awards, which often means applicants need to rely on NIH institute-specific guidance, K23 policy limits, and the budget and effort rules in the full funding opportunity announcement and related NIH policy documents. Overall, this K23 parent announcement is best understood as a mentored career development pathway for clinically trained investigators whose research requires direct involvement of human participants and who need dedicated time and mentorship to develop into independent patient-oriented researchers.

  • The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.361, 93.853, 93.865, 93.866, 93.867.
  • This funding opportunity was created on 2020-05-11.
  • Applicants must submit their applications by 2024-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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