Opportunity Information: Apply for PA 16 342
Methods Development in Natural Products Chemistry (R41/R42) is a National Institutes of Health (NIH) funding opportunity announcement (FOA) that supports Small Business Technology Transfer (STTR) projects aimed at creating highly innovative methods and technologies for natural products chemistry. The central goal is to push the field forward by enabling new or significantly improved ways to discover, characterize, analyze, or otherwise work with natural products, which are often complex molecules derived from living organisms and frequently serve as starting points or inspiration for therapeutics and research tools. The emphasis is on methods development and technology advancement rather than routine applications of existing techniques, meaning projects are expected to introduce meaningful innovation that can change what is practically possible in natural products research.
The FOA uses the NIH STTR mechanisms R41 and R42, which are structured to help small businesses translate early-stage scientific ideas into practical products or platforms through a phased approach. In general terms, Phase I (R41) is typically used to establish feasibility and proof of concept, while Phase II (R42) supports further development, optimization, and steps toward commercialization or broader adoption. Because it is an STTR opportunity, applicants should expect the project to involve a formal partnership between an eligible small business concern (SBC) and a research institution, aligning scientific expertise with a development and commercialization pathway.
Eligibility is focused on small businesses. Non-U.S. (foreign) institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply. However, the FOA notes that "foreign components" (as defined in the NIH Grants Policy Statement) may be allowed, which typically means certain discrete elements of the work could be conducted outside the U.S. if they meet NIH policy requirements and are well-justified, but the applicant organization itself must be eligible and U.S.-based under STTR rules.
Key administrative details include the FOA number PA-16-342 and the listing under CFDA 93.213, with NIH as the sponsoring agency. The opportunity category is discretionary and the funding instrument is a grant, within the broader health funding activity category. The FOA was created on 2016-06-23 and lists an original closing date of 2018-01-30. The source data provided does not specify an award ceiling or the expected number of awards, indicating those details were either not included in the excerpt or were not set in that summary record.
Overall, this opportunity is best suited for U.S. small businesses that are building new tools, workflows, instrumentation, analytical methods, computational approaches, or enabling technologies that address bottlenecks in natural products chemistry. Strong applications would typically make a clear case that the proposed method is genuinely enabling, fills an unmet need, and can be developed through the STTR model into something broadly useful for research and, potentially, downstream health-related discovery and development.Apply for PA 16 342
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods Development in Natural Products Chemistry (R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213.
- This funding opportunity was created on 2016-06-23.
- Applicants must submit their applications by 2018-01-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Frequently Asked Questions (FAQs)
What is the "Methods Development in Natural Products Chemistry (R41/R42)" funding opportunity?
It is a National Institutes of Health (NIH) funding opportunity announcement (FOA) that supports Small Business Technology Transfer (STTR) projects focused on creating highly innovative methods and technologies for natural products chemistry. The intent is to enable new or significantly improved ways to discover, characterize, analyze, or otherwise work with natural products.
What is the main goal of this FOA?
The central goal is to push the natural products chemistry field forward by supporting methods development and technology advancement that meaningfully expands what is practically possible in natural products research.
What kinds of scientific or technical work does the FOA emphasize?
The emphasis is on developing new methods and technologies rather than using existing techniques in routine ways. Projects are expected to introduce meaningful innovation that can change capabilities in natural products discovery, characterization, or analysis.
What are "natural products" in the context of this opportunity?
Natural products are often complex molecules derived from living organisms. They frequently serve as starting points or inspiration for therapeutics and research tools, and the FOA targets innovations that improve how these molecules are found and studied.
Which NIH funding mechanisms are used?
This FOA uses the NIH STTR mechanisms R41 and R42.
How do Phase I (R41) and Phase II (R42) generally differ?
In general terms, Phase I (R41) is typically used to establish feasibility and proof of concept. Phase II (R42) supports further development, optimization, and steps toward commercialization or broader adoption.
Is this opportunity specifically for small businesses?
Yes. Eligibility is focused on small businesses applying under the STTR model.
Does the FOA require a partnership between a small business and a research institution?
Yes. Because it is an STTR opportunity, applicants should expect a formal partnership between an eligible small business concern (SBC) and a research institution, combining scientific expertise with development and commercialization planning.
Are non-U.S. (foreign) institutions eligible to apply?
No. Non-U.S. (foreign) institutions are not eligible to apply under this opportunity.
Are non-U.S. components of U.S. organizations eligible to apply?
No. Non-U.S. components of U.S. organizations are also not eligible to apply.
Are any foreign activities allowed at all?
The FOA notes that "foreign components" (as defined in the NIH Grants Policy Statement) may be allowed. This typically means discrete elements of the work could be conducted outside the U.S. if they meet NIH policy requirements and are well-justified. The applicant organization itself still must be eligible and U.S.-based under STTR rules.
What is the FOA number?
The FOA number is PA-16-342.
What CFDA listing is associated with this opportunity?
The listing provided is CFDA 93.213.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What is the opportunity category and funding instrument?
The opportunity category is discretionary. The funding instrument is a grant.
What is the broader funding activity area?
It is within the broader health funding activity category.
When was the FOA created?
The FOA was created on 2016-06-23.
What closing date is listed for this opportunity?
The source information lists an original closing date of 2018-01-30.
Does the provided information include an award ceiling?
No. The source data provided does not specify an award ceiling.
Does the provided information include the expected number of awards?
No. The source data provided does not specify the expected number of awards.
What types of projects are a good fit for this FOA?
This opportunity is best suited for U.S. small businesses building new tools, workflows, instrumentation, analytical methods, computational approaches, or other enabling technologies that address bottlenecks in natural products chemistry.
What makes a project "innovative" under this FOA?
Projects are expected to go beyond routine applications of existing techniques and instead propose genuinely enabling methods or technologies that fill an unmet need and significantly improve how natural products research can be done.
How should applicants think about impact and adoption?
The FOA highlights development through the STTR model into a practical product or platform, with Phase II generally supporting steps toward commercialization or broader adoption, and an overall focus on broad usefulness for research and downstream health-related discovery and development.
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