Opportunity Information: Apply for RFA AI 24 071
The NIH funding opportunity titled "Promoting Innovative Research in Treponema pallidum Pathogenesis (R21 Clinical Trial Not Allowed)" (Funding Opportunity Number RFA-AI-24-071) is a discretionary grant program designed to push forward basic and early-stage, exploratory research on Treponema pallidum, the bacterium that causes syphilis. The central goal is to improve scientific understanding of how this pathogen causes disease, including the biological mechanisms it uses to infect, persist, evade host defenses, and drive tissue damage. Because the mechanism of pathogenesis for T. pallidum remains difficult to study compared with many other bacteria, the emphasis here is on innovative, potentially higher-risk ideas that can open up new directions rather than incremental extensions of well-established projects.
This opportunity uses the NIH R21 mechanism, which is commonly intended for exploratory and developmental research. In practical terms, that usually means applicants are expected to propose focused projects that can generate strong preliminary insights, new tools, new hypotheses, or proof-of-concept data that could later support larger, longer-term applications. The NOFO explicitly states "Clinical Trial Not Allowed," which means the supported work must not include prospective assignment of human participants to an intervention to study health-related outcomes. Applicants can still often work with clinical specimens, existing datasets, observational human research (depending on the specifics and NIH definitions), animal models, in vitro systems, and computational approaches, as long as the project does not meet the NIH definition of a clinical trial.
The scientific scope is centered on T. pallidum bacterial pathogenesis, so projects may fit if they aim to clarify how the organism interacts with the host at the molecular, cellular, and immunological levels. Depending on the field, this could involve studying bacterial surface structures and antigenic variation, mechanisms of immune evasion and persistence, dissemination within the host, tissue tropism, host immune responses that contribute to protection versus pathology, or factors that influence transmission and disease progression. Work that develops or applies enabling technologies can also be a strong fit in this space because T. pallidum has historically been challenging to manipulate and culture, making new methods, model systems, and assays especially valuable to the broader research community.
The funding activity category is Health, and the CFDA number listed is 93.855, aligning the program with NIH infectious disease research priorities. The administering agency is the National Institutes of Health. The original closing date provided is November 4, 2024, and the NOFO was created on August 2, 2024. The listing does not provide an award ceiling or expected number of awards in the source data shown, so applicants would typically need to consult the full announcement text for budget limits, project period expectations, and any institute-specific requirements that commonly accompany R21 submissions.
Eligibility is broad and includes a wide range of organization types, reflecting NIH's standard approach to encouraging diverse institutional participation. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; and small businesses. The opportunity also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-U.S. entities (foreign organizations), and U.S. territories or possessions. That list signals an intent to include institutions serving underserved populations and to allow international participation where appropriate, which can be important for infectious disease research with global relevance.
Overall, this NOFO is best read as an invitation for researchers to bring fresh ideas and creative approaches to unanswered questions about syphilis pathogenesis, without proposing interventional clinical trials. Competitive projects will usually be those that clearly articulate a gap in the field, explain why existing methods have not been sufficient, and propose a feasible but innovative strategy that can produce meaningful advances within an exploratory R21-style project scope.Apply for RFA AI 24 071
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Promoting Innovative Research in Treponema pallidum Pathogenesis (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on 2024-08-02.
- Applicants must submit their applications by 2024-11-04. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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